Scanning laser polarimetry in normal subjects and patients. Pdf comparison between gdx vcc scanning laser polarimetry. Purposeto compare sensitivity and specificity of retinal nerve fiber layer thickness rnflt measurements made using rtvue100 fourierdomain optical coherence tomography rtvueoct and scanning. Original contribution retinal imaging by laser polarimetry and optical coherence tomography evidence of axonal degeneration in multiple sclerosis. Analytical methods for scanning laser polarimetry osa. Scanning laser polarimetry in glaucoma t anuj dada, reetika sharma, dewang angmo, gautam sinha, shibal bhartiy a, sanjay k mishra, anita panda, ramanjit sihota. Hence, the measurement of rnfl thickness has come up. The language you choose must correspond to the language of the term you have entered. This article will discuss information on evaluation of the intrabulbar structure of the optic nerve as it relates to glaucoma, with particular emphasis on three imaging devices, confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry.
Scanning laser polarimetry, retinal birefringence, light retardation, retinal nerve fiber layer, glaucoma, anterior segment birefringence. Optical coherence tomography, scanning laser polarimetry. I read with interest the article titled factors affecting image acquisition during scanning laser polarimetry by tien hoh et al. For example, the rtvue xr oct avanti optovue is an oct system. Pdf comparison of scanning laser polarimetry using. Factors affecting image acquisition during scanning laser. The main birefringent intraocular tissues are the cornea, lens and the retina. Pdf the quality of reporting of diagnostic accuracy. Detection of glaucoma with scanning laser polarimetry. Scanning laser polarimetry an overview sciencedirect. Scanning laser polarimetry of the retinal nerve fiber layer. Technology today the nerve fiber layer and scanning laser. Objective to determine if scanning laser polarimetry slp measures form birefringence of the retinal nerve fiber layer rnfl methods consecutive patients with either acute unilateral disc edema or chronic diffuse unilateral disc atrophy underwent slp using the gdx nerve fiber analyzer laser diagnostic technologies inc, san diego, calif. Optical coherence tomography applies the principle of interferometry to determine the interface between different ocular tissues.
Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry. Gdxpro scaning laser polarimetry glaucoma carl zeiss. Optical coherence tomography and scanning laser polarimetry slp are the techniques that utilize the. A basic understanding of how birefringence and retardation is vital to understand how this tech pictures the optic nerve. Ophthalmologic techniques that evaluate the posterior.
Technology today the nerve fiber layer and scanning. The first commercial scanning laser polarimeter was the the nerve fiber layer and scanning laser polarimetry the history and utility of this technology. Scanning laser polarimetry reveals status of rnfl integrity in eyes with optic nerve head swelling by oct mark j. Imaging polarimetry in macular disease with scanning laser. Retinal imaging by laser polarimetry and optical coherence. A number of confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and optical coherence tomography oct devices have been cleared by the u. Scanning laser polarimetry is performed by a confocal scanning laser ophthalmoscope with an integrated polarimeter gdxvcc. Voci con modulo citazione e parametro pagine voci con modulo citazione e parametro coautori stub. In addition to standard automated perimetry, gonioscopy, fundus photography, and stereophotography, other advanced, highresolution methods for imaging the eye in glaucoma are explained in detail.
Optical coherence tomography oct shows retinal nerve. Zeiss gdx pro 8000 is the only commercially available, currentgeneration scanning laser polarimeter. Birefringence and depolarization were observed in the area with deep retinal lesions in macular disease. In the retina, the parallel arrangement of the microtubules. Pdf scanning laser polarimetry in eyes with exfoliation. Scanning laser polarimetry slp is based on the birefringence properties of ganglion cell axon neurotubules that alter the laser scanning beam polarization acco rding to the rnfl thickness. Pdf scanning laser polarimetry in monkey eyes using. These results are often considered along with other findings to make diagnostic and therapeutic decisions.
Each of these diagnostic tools is based on different imaging modalities. Scanning laser polarimetry of edematous and atrophic optic. Scanning laser polarimetry versus matrix perimetry, optical coherence tomography, and retinal nerve fiber layer photography using heidelberg retina angiograph 1. Longterm followup of scanning laser polarimetry and confocal scanning laser ophthalmoscopy in normal tension glaucoma kremmer s 1,2, darwesh s 2, anastassiou g 1,2, steuhl kp and selbach jm1,2 1eye hospital, evangelisches krankenhaus gelsenkirchen, munckelstr. Scanning laser polarimetry in eyes with exfoliation syndrome. Optic nerve and retinal nerve fiber imaging eyewiki. Clinical studies in scanning laser polarimetry core. Pdf retinal degeneration in progressive supranuclear. Retinal ganglion cells and their axons represent the. Scanning laser polarimetry laser light enters eye at specific orientation. Scanning laser polarimetry came onto the market in 1993. Aim to evaluate the applicability of imaging devices spectraldomain optical coherence tomography cirrus sdoct, scanning laser polarimetry gdx and scanning laser ophthalmoscopy heidelberg retinal tomograph, hrt3 for glaucoma screening in a middleaged unselected population. Background optical coherence tomography oct and scanning laser polarimetry with variable corneal compensation gdx are similar yet provide information on different aspects of retinal nerve fiber layer rnfl structure thickness values similar to histology for oct vs birefringence of.
Pdf optical coherence tomography, scanning laser polarimetry. Methods participants of the populationbased northern finland birth cohort eye study, aged 45 to 49 years. Recently, scanning laser polarimetry was used to selectively emphasize the different layers of the retina. Scanning laser polarimetry an overview sciencedirect topics. Comparison of scanning laser polarimetry using variable corneal compensationand retinal nerve fiber layer photography for detection of glaucoma. Pdf effect of peripapillary chorioretinal atrophy on gdx. Scanning laser polarimetry slp has undergone multiple hardware and software changes, particularly in neutralizing anterior segment birefringence, to improve its ability to recognize retinal nerve fiber layer retardation. To confirm the origin of these polarization changes, layer by layer analysis is required.
To evaluate and compare the diagnostic accuracies for glaucoma detection of scanning laser polarimetry slp with enhanced corneal compensation gdx. Scanning laser polarimetry is a technique for assessing the thickness of the retinal nerve fiber layer in vivo. Gdxpro scaning laser polarimetry glaucoma carl zeiss meditec international. Food and drug administration fda through the 510k process for imaging the posterior eye segment.
In all subjects, both eyes were scanned with the gdx vcc, starting with the right eye. The commercially available scanning laser ophthalmoscope is made by heidelberg engineering, and is called. Near infrared wavelength laser double passes the retinal nerve fiber layer nfl and is split into 2 parallel rays by the birefringent fibers. Scanning laser polarimetry measures change in the linear polarization of light retardation. Optical coherence tomography, scanning laser polarimetry and. Scanning laser polarimetry slp has been proposed as a useful diagnostic test for glaucoma. One eye from 84 healthy individuals and 83 patients with early to moderate glaucomatous visual field loss 167 eyes was assessed with a scanning laser polarimeter laser diagnostic technologies, san diego, calif. Confocal scanning laser ophthalmoscopy is a technique designed to evaluate the threedimensional structure of the optic disc, which has been described in chapter. Correlation between local glaucomatous visual field defects and loss of nerve fiber layer thickness measured with scanning laser polarimetry and spectral domain optical coherence tomography. Analytical model of scanning laser polarimetry for retinal nerve. The subjects are multiethnic and 1882 polarimetria old.
Assessment of nerve fiber layer in diabetic patients with. The model is based on image series of 23 healthy eyes and incorporates colored noise, incomplete cornea compensation and masking by the retinal blood vessels. Scanning laser polarimetry is an imaging technology that is utilized to measure peripapillary rnfl thickness. Gdxpro, the worlds only scanning laser polarimeter, provides a unique measurement derived from both rnfl thickness and rnfl structural organization. Though the technology has been available for several years, recent advances have resulted in improved imaging capabilities that may enhance clinicians ability to identify and follow the progression of glaucoma. Scanning laser polarimetry is the use of polarised light to measure the thickness of the retinal nerve fiber layer as part of a glaucoma workup.
These techniques are optical coherence tomography oct, scanning laser polarimetry slp and confocal scanning laser ophthalmosopy cslo. This so called retardation is thought to be linearly correlated with nerve fiber layer thickness. Optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy in retinal nerve fiber layer measurements of glaucoma patients farsad fanihagh 1, stephan kremmer, 1, 2, gerasimos anastassiou 1, 2, maurice schallenberg 2, 3, klauspeter steuhl 2, michael selbach 1, 2. Scanning laser polarimetry in monkey eyes using variable corneal polarization compensation. Three separate scans were obtained, and a baseline scan was created and used in the analyses. Scanning laser polarimetry of a patient with degenerative myopia demonstrating irregular high spikes in the tsnit temporal, superior, nasal, inferior, temporal graph and an overall increase in retinal nerve fibre layer thickness in all peripapillary quadrants in the colour thickness map. Although these techniques differ, the objective is the. Scanning laser polarimetry slp, a technology for glaucoma diagnosis, uses. In addition to standard automated perimetry, gonioscopy, fundus photography, and stereophotography, other advanced, highresolution methods for imaging the eye in glaucoma are explained in detail, including ultrasound biomicroscopy, confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and spectral domain optical coherence tomography. Spectraldomain optical coherence tomography and scanning. The effects of poor anterior segment compensation on scanning laser polarimetry measurements of. To develop a quantitative understanding of scanning laser polarimetry slp for. Gdxpro uses a nearinfrared laser 780nm in a raster pattern to image the macula and peripapillary region. Effects of inadequate anterior segment compensation on.
It uses both a polarimeter an optical device to measure linear polarization change and a scanning laser ophthalmoscope, to measure the thickness of the nerve fiber layer of the retina. Detection of glaucoma using scanning laser polarimetry with. Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry. To determine the correlations and strength of association between different imaging systems in analyzing the retinal nerve fiber layer rnfl of glaucoma patients. Ophthalmic surgery, lasers and imaging retina abstract. Aims to examine the changes in the retinal nerve fibre layer nfl thickness with age and myopia in normal population methods retinal nerve fibre layer thickness was measured with a scanning laser polarimeter nfai in 180 normal subjects of varying age range 783 years and in 110 eyes of 85 patients with myopia of varying degrees range. Pdf to compare the abilities of scanning laser polarimetry with the variable corneal compensator gdx vcc with.
The optical coherence tomography oct, confocal scanning laser ophthalmoscopy cslo, and scanning laser polarimetry slp are three prevailing glaucoma imaging technologies that have evolved rapidly over the recent years in both hardware and software configurations. Confocal scanning laser ophthalmoscopy, glaucoma, oct, retinal nerve fiber layer, scanning laser polarimetry. Scanning laser polarimetry images were obtained using a commercial gdx vcc system version 5. Scanning computerized ophthalmic diagnostic imaging devices. The retardation value is proportionate to the thickness of the rnfl fig. Kupersmith,1 randy kardon,2 mary durbin,3 melissa horne,3 and julia shulman4 purpose. Diagnostic performance of modern imaging instruments in. Relationship between visual field sensitivity and retinal. Comparison of diagnostic accuracy of the rtvue fourier. Imaging polarimetry in macular disease with scanning laser polarimetry and.
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